Rapid Zubsolv Detox under sedation is a medical detoxification treatment for Zubsolv dependence. It consists of sedating the patient and removing Zubsolv from the brain receptor with an opiate blocker that will precipitate acute withdrawals. These withdrawals will pass during the sedation period. Then the opioid receptor will be blocked by a long-acting Naltrexone implant.

It is recommended to stay on Naltrexone maintenance therapy for at least one year to allow the brain to heal from the damage caused by the drug use. The protocol takes about one hour to complete. Patients will stay overnight to complete the detoxification and discharged the next day. Aftercare with psychotherapy and 12 step are recommended.


Zubsolv is used as an opiate agonist therapy for the treatment of opiate dependence. Zubsolv is a combination of buprenorphine and naloxone. The opiate blocker Naloxone is part of Zubsolv to prevent intravenous injection of Zubsolv. It is the second most widely used trade name of the buprenorphines, Suboxone being the most used. It is a semi-synthetic opioid derived from thebaine of the poppy seed. It is a partial agonist to the Mu opioid receptor and antagonist at the Kappa opioid receptor. Zubsolv half-life is 24-42 hours. It is an opioid.

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Zubsolv can cause nausea, vomiting, drug withdrawal syndrome, headache, sweating, mouth numbness, constipation, tongue pain, redness of the mouth, attention problems, palpitation, reduced sleep, and decreased libido.


Zubsolv is a long-acting opioid, so withdrawals start several hours to days after its discontinuation and have been reported by patients to last weeks and even months. Zubsolv withdrawals are more severe than some of the other potent opiates.

Withdrawals include anxiety, constipation, headache, hot-cold flashes, leg cramps, nausea, pain, restlessness, vomiting, and sweating. Insomnia usually lasts several weeks to months. It is the withdrawals that keep the patient going back to the use of opiate and consequently unable to break the cycle of addiction.


Taking benzodiazepines, sedatives, tranquilizers or drinking alcohol while on Zubsolv can result in overdose and even death.

Overdose symptoms from Zubsolv include cold, clammy skin, hypotension (low blood pressure), very sleepy and sluggish, slow, shallow breathing, respiratory depression, coma, and death.

Zubsolv ABUSE

When opiate agonist therapy with Zubsolv is used for the opioid-dependent patient, it is done to satisfy the need of the opioid Mu receptor that is dependent on opiates. By this replacement therapy, the patient is still dependent on opiates. Consequently, the patient will still be dependent on Zubsolv and when it is discontinued, the withdrawal syndrome will start.

Zubsolv can be abused as some patients report a “high” with its use. Zubsolv is used by some patients to prevent withdrawals when they are not able to find their opiate of choice.

Improper use and abuse of Zubsolv can lead to dependence, tolerance, and addiction.

Opiates can be habit forming, causing not only physical, but also psychological dependence. Withdrawals may occur if the dose of the opiates is reduced or discontinued after long term use.

Using opiates for an extended period of time can lead to tolerance, where the user needs to increase the dosage of their opiates to achieve the desired effect, whether the desired effect is pain control or euphoria.

Once the patient develops a tolerance, it becomes even more difficult to stop using due to the withdrawals. Symptoms of withdrawals are an indication of physical dependence and addiction to the opiate Zubsolv. Most patients describe withdrawals as the worst, most frightening experience one will ever encounter. One can only imagine the excruciating pain when the opiate user says that they’d rather die than go through the withdrawals. Zubsolv physical dependence symptoms, such as withdrawals, lead to psychological dependence. That is when addiction takes over the mind and life of the Zubsolv opiate user.

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