Zubsolv is a long-acting opioid, so withdrawals start several hours to days after its discontinuation and have been reported by patients to last weeks and even months. Zubsolv withdrawals are more severe than some of the other potent opiates.
Withdrawals include anxiety, constipation, headache, hot-cold flashes, leg cramps, nausea, pain, restlessness, vomiting, and sweating. Insomnia usually lasts several weeks to months. It is the withdrawals that keep the patient going back to the use of opiate and consequently unable to break the cycle of addiction.